Author's response to reviews Title: Induction of G1 and G2/M cell cycle arrests by the dietary compound 3,3'-diindolylmethane in HT-29 human colon cancer cells Authors:

نویسندگان

  • Hyun Ju Choi
  • Young Lim
  • Jung Han
  • Yoon Park
  • Thomas Szekeres
  • Farrukh Afaq
چکیده

We have conducted additional experiments andd addedd the results showing that DIM induces bothh G11 andd G2/M arrest inn HT-299 humann colonn cancer cells inn a

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Induction of G1 and G2/M cell cycle arrests by the dietary compound 3,3'-diindolylmethane in HT-29 human colon cancer cells

BACKGROUND 3,3'-Diindolylmethane (DIM), an indole derivative produced in the stomach after the consumption of broccoli and other cruciferous vegetables, has been demonstrated to exert anti-cancer effects in both in vivo and in vitro models. We have previously determined that DIM (0 - 30 micromol/L) inhibited the growth of HT-29 human colon cancer cells in a concentration-dependent fashion. In t...

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تاریخ انتشار 2009